An analysis of the essential mineral selenium conducted by Children's Hospital Oakland Research Institute (CHORI) scientists (1) suggests that adequate intake of essential mineral selenium could help to prevent age-related conditions such as immune dysfunction, cardiovascular disease, and cancer. Selenium is present in dietary plants if the soil has adequate amounts, which is generally true in the U.S., but not in parts of China, Russia, and most of Western Europe.
The analysis, conducted by CHORI Associate Staff Scientist, Joyce McCann, PhD, and Senior Scientist, Bruce Ames, PhD was designed to test Dr. Ames' "triage" theory that provides a new basis for determining the optimum intake of individual vitamins and minerals by measuring long-term insidious damage associated with aging, and that has major implications for preventive medicine. The selenium analysis strongly supports the theory and is published in the March 2011 issue of the The Federation of American Societies for Experimental Biology (FASEB) Journal. The analysis provides a consistent scientific basis for establishing optimum vitamin and mineral intakes, which will add credence to recommendations for improving inadequacies in micronutrient intake of the American diet.
Dr. Ames proposed the triage theory in 2006 (2) to explain numerous observations from his own lab and the scientific literature. The triage theory explains why diseases associated with aging (and the pace of aging itself) may be unintended consequences of mechanisms developed during evolution to protect metabolic processes against episodic vitamin and mineral shortages. Dr. Ames reasoned that these mechanisms are focused on preserving vitamin and mineral-dependent functions required for animals to survive for reproduction, at the expense of other functions required to sustain long-term health -- not a priority for evolution. As a result, Dr. Ames proposed that modest shortages in vitamin and mineral (against which ("essential") functions are protected) lead to insidious metabolic damage in so-called "less critical functions" that over time accelerates aging and may lead to diseases of aging such as cancer, heart disease, and dementia. If correct, the triage theory has widespread implications for public health because modest vitamin and mineral deficiencies are quite common. It also suggests a new scientifically based and consistent strategy for establishing optimal vitamin and mineral intake standards, and it provides a research strategy to uncover early biomarkers of chronic disease.
This selenium analysis is the second in a series of literature-based studies conducted by Drs. McCann and Ames to test the basic premises of the triage theory by constructing triage-based biological profiles of individual vitamin and minerals. A previous analysis of published evidence on vitamin K (3), also strongly supported the theory.
http://www.medicalnewstoday.com/articles/222171.php
The analysis, conducted by CHORI Associate Staff Scientist, Joyce McCann, PhD, and Senior Scientist, Bruce Ames, PhD was designed to test Dr. Ames' "triage" theory that provides a new basis for determining the optimum intake of individual vitamins and minerals by measuring long-term insidious damage associated with aging, and that has major implications for preventive medicine. The selenium analysis strongly supports the theory and is published in the March 2011 issue of the The Federation of American Societies for Experimental Biology (FASEB) Journal. The analysis provides a consistent scientific basis for establishing optimum vitamin and mineral intakes, which will add credence to recommendations for improving inadequacies in micronutrient intake of the American diet.
Dr. Ames proposed the triage theory in 2006 (2) to explain numerous observations from his own lab and the scientific literature. The triage theory explains why diseases associated with aging (and the pace of aging itself) may be unintended consequences of mechanisms developed during evolution to protect metabolic processes against episodic vitamin and mineral shortages. Dr. Ames reasoned that these mechanisms are focused on preserving vitamin and mineral-dependent functions required for animals to survive for reproduction, at the expense of other functions required to sustain long-term health -- not a priority for evolution. As a result, Dr. Ames proposed that modest shortages in vitamin and mineral (against which ("essential") functions are protected) lead to insidious metabolic damage in so-called "less critical functions" that over time accelerates aging and may lead to diseases of aging such as cancer, heart disease, and dementia. If correct, the triage theory has widespread implications for public health because modest vitamin and mineral deficiencies are quite common. It also suggests a new scientifically based and consistent strategy for establishing optimal vitamin and mineral intake standards, and it provides a research strategy to uncover early biomarkers of chronic disease.
This selenium analysis is the second in a series of literature-based studies conducted by Drs. McCann and Ames to test the basic premises of the triage theory by constructing triage-based biological profiles of individual vitamin and minerals. A previous analysis of published evidence on vitamin K (3), also strongly supported the theory.
http://www.medicalnewstoday.com/articles/222171.php
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