Tuesday, November 29, 2011

Growth Hormone Increases Bone Formation In Obese Women

In a new study presented today at the annual meeting of the Radiological Society of North America (RSNA), growth hormone replacement for six months was found to increase bone formation in abdominally obese women.

"This is the first time that the effects of growth hormone on bone have been studied in obesity," said the study's lead author, Miriam A. Bredella, M.D., a radiologist at Massachusetts General Hospital and assistant professor of radiology at Harvard Medical School in Boston. "Growth hormone is extremely important for bone health, and women with increased belly fat have weaker bones and reduced growth hormone levels."

According to the Centers for Disease Control and Prevention (CDC), approximately one-third (33.8 percent) of U.S. adults are obese. The CDC defines obesity as having a body mass index (BMI) of 30 or more. Obesity is associated with many health problems, including cardiovascular and joint diseases, diabetes, high cholesterol, asthma and sleep apnea.

In a previous study, Dr. Bredella found that women with excess abdominal fat were at increased risk for bone loss. For this study, the researchers set out to determine if administration of growth hormone would increase bone formation.

Seventy-nine premenopausal, abdominally obese women with a mean age of 36 and a mean BMI of 35 participated in the six-month, randomized, placebo-controlled trial. Each woman underwent an MR spectroscopy exam to evaluate bone marrow fat. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DXA). Abdominal fat and thigh muscle area were assessed with computed tomography (CT). Baseline measurements were compared with follow-up results at six months to determine change.

The baseline measurements showed that 32 percent of the women had osteopenia and one woman had osteoporosis. After six months, women who had received growth hormone showed increased bone formation, increased bone marrow fat and muscle mass, and higher levels of Vitamin D. They also exhibited a loss in abdominal fat compared to the placebo group. Women with the most abdominal fat loss had greater increases in bone formation.

"In addition to bone formation, our results also showed that growth hormone increases muscle mass, decreases belly fat and lowers cardiovascular risk markers, such as cholesterol and C-reactive protein," Dr. Bredella said.

According to Dr. Bredella, the risks are minimal, and this therapy could also be applied to non-obese and postmenopausal women. "As aging is associated with reduced growth hormone secretion, this could be a potential therapy for postmenopausal osteoporosis," she said.

Coauthors are Eleanor Lin, Daniel J. Brick, Anu Gerweck, Lindsey M. Harrington, Martin Torriani, M.D., Bijoy Thomas, M.D., Anne Klibanski, M.D., and Karen Miller, M.D. This research was supported by the National Institutes of Health (NIH grants R01 HL-077674 and K23 RR-23090).

Note: Copies of RSNA 2011 news releases and electronic images will be available online at RSNA.org/press11 beginning Monday, Nov. 28.

RSNA is an association of more than 48,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill.

AT A GLANCE

Growth hormone replacement increases bone formation and muscle mass and decreases abdominal fat in obese women.

Increased abdominal fat is a risk factor for bone loss.

Growth hormone also lowers cardiovascular risk markers, such as cholesterol.

One-third of U.S. adults are obese.
http://www.medicalnewstoday.com/releases/238335.php


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A Photoshop Reality Check: Reality In The Eye Of The Beholder

You know they couldn't possibly look that good. But what did those models and celebrities look like before all the retouching? How different is the image we see from the original?

Dartmouth Computer Science Professor Hany Farid and Eric Kee, a PhD student at Dartmouth College, are proposing a method to not only answer such questions but also to quantify the changes.

As Farid writes, "Impossibly thin, tall, and wrinkle- and blemish-free models are routinely splashed onto billboards, advertisements, and magazine covers." He says that this is "creating a fantasy of sorts." Going beyond considerations of aesthetics or any dishonesty of photo editors or advertisers, Farid and Kee voice public health concerns.

In a paper published in the Proceedings of the National Academy of Sciences (PNAS) on November 28, 2011, they point out that these highly idealized images have been linked to eating disorders and body image dissatisfaction in men, women, and children. The authors note that the American Medical Association has recently adopted a policy to "discourage the altering of photographs in a manner that could promote unrealistic expectations of appropriate body image."

There have already been repercussions in the United Kingdom. A Reuters news story from July 2011 reports: "Two L'Oreal cosmetics adverts [advertisements] featuring actress Julia Roberts and supermodel Christy Turlington were banned in Britain by the Advertising Standards Agency, following complaints by MP [Member of Parliament] Jo Swinson. Liberal Democrat MP Swinson said the magazine adverts for foundations made by Maybelline and Lancome, both owned by L'Oreal, were misleading because the photos had been digitally altered." On a prior occasion, L'Oreal had been forced to add a disclaimer to another ad.

But Farid and Kee assert that outright bans or simple disclaimers may not be addressing the issue fairly or completely. They are seeking a way to for advertisers to truthfully and accurately characterize the extent to which an image has been altered while allowing the public to make informed judgments. The goal is to create a metric that provides an objective assessment of how much alteration has been made.

The authors propose a rating system that takes into account common practices such as cropping and color adjustment while providing assessment of other kinds of modifications that dramatically change a person's appearance. They consider geometric alterations such as slimming legs, adjusting facial symmetry, and correcting posture, as well as photometric manipulations that might include removing wrinkles, "bags" under the eyes and skin blemishes.

"We start with the before and after digital images from which we automatically estimate the geometric and photometric changes, effectively reverse engineering the manipulations that a photo retoucher has made," Farid says.

In the study, to crosscheck and validate their metric, human observers were asked to compare and rank the differences in hundreds of pairs of before and after retouching images. The results correlated highly with the mathematical metric.

"Such a rating may provide incentive for publishers and models to reduce some of the more extreme forms of digital retouching that are common today," the authors conclude, but they add, "It remains to be seen if this rating can mediate the adverse effects of being inundated with unrealistic body images."
http://www.medicalnewstoday.com/releases/238353.php

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Ocean Spray Original Flavor Craisins Recalled, Hair-like Metal Fragments Found

Small hair-like fragments were found in certain lots of Original Flavor Craisins Dried cranberries, triggering a voluntary recall, the FDA (Food and Drug Administration) and Ocean Spray Cranberries Inc. have announced. The affected produce comes in 5-ounce, 10-ounce and 48-ounce packages. The company emphasized that the hair-like metal fragments are extremely unlikely to cause any harm or injury to consumers, it added that this current recall is a precautionary measure.

Craisins are fresh cranberries that have been partially dehydrated, a process similar to making raisins from grapes. Craisins are popular for making salads, added to bread, cereals, or simply eaten on their own. The word craisin is a registered trademark of Ocean Spray Cranberries Inc. Other manufacturers who make partially dried cranberries are not allowed to use the term "craisins" for their products.

The FDA and the makers of craisins say they have received no reports of consumer complaints.

Ocean Spray says it initiated this recall "out of an abundance of caution to ensure the safety of our consumers".

craisins
Certain 5-oz, 10-oz, and 48-oz Craisins® Code Dates Affected

Ocean Spray says that all other products not mentioned in this recall are fine to buy and consume.

The following products form part of this recall:
  • 5 oz Craisins® UPC: 00293-000
    Best buy dates followed by the letter "M" - Oct 27, 2012 M
  • 10 oz Craisins® UPC: 29456-000 and 29464-000
    Best buy dates followed by the letter "M" - Oct 27 2012 M, Oct 28 2012 m, Oct 29 2012 M
  • 48 oz Craisins® UPC: 00678-318
    Best buy dates followed by the letter "M" - Oct 27 2012 M, Oct 28 2012 M, Nov 3 2012 M, Nov 4 to 7 2012 M, Nov 10 & 11 2012 M
  • 10 lb bulk ingredient & foodservice UPC: 03477-000
    Best buy dates followed by the letter "M" - Oct 30 & 31 2013 M, Nov 1 to 5 2013 M
If you have bought and still have any of these recalled craisins you should destroy it, save the UPC label and best buy date and telephone 1-800-662-3263 (Ocean Spray Consumer Hotline) for a coupon replacement.

Written by Christian Nordqvist
http://www.medicalnewstoday.com/articles/238288.php

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Sunday, November 27, 2011

Quality Of Sleep Impacted By Physical Activity

People sleep significantly better and feel more alert during the day if they get at least 150 minutes of exercise a week, a new study concludes.

A nationally representative sample of more than 2,600 men and women, ages 18-85, found that 150 minutes of moderate to vigorous activity a week, which is the national guideline, provided a 65 percent improvement in sleep quality. People also said they felt less sleepy during the day, compared to those with less physical activity.

The study, out in the December issue of the journal Mental Health and Physical Activity, lends more evidence to mounting research showing the importance of exercise to a number of health factors. Among adults in the United States, about 35 to 40 percent of the population has problems with falling asleep or with daytime sleepiness.

"We were using the physical activity guidelines set forth for cardiovascular health, but it appears that those guidelines might have a spillover effect to other areas of health," said Brad Cardinal, a professor of exercise science at Oregon State University and one of the study's authors.

"Increasingly, the scientific evidence is encouraging as regular physical activity may serve as a non-pharmaceutical alternative to improve sleep."

After controlling for age, BMI (Body Mass Index), health status, smoking status, and depression, the relative risk of often feeling overly sleepy during the day compared to never feeling overly sleepy during the day decreased by 65 percent for participants meeting physical activity guidelines.

Similar results were also found for having leg cramps while sleeping (68 percent less likely) and having difficulty concentrating when tired (45 percent decrease).

Paul Loprinzi, an assistant professor at Bellarmine University is lead author of the study, which was conducted while he was a doctoral student in Cardinal's lab at OSU. He said it is the first study to examine the relationship between accelerometer-measured physical activity and sleep while utilizing a nationally representative sample of adults of all ages.

'Our findings demonstrate a link between regular physical activity and perceptions of sleepiness during the day, which suggests that participation in physical activity on a regular basis may positively influence an individual's productivity at work, or in the case of a student, influence their ability to pay attention in class," he said.

Cardinal said past studies linking physical activity and sleep used only self-reports of exercise. The danger with this is that many people tend to overestimate the amount of activity they do, he said.

He added that the take-away for consumers is to remember that exercise has a number of health benefits, and that can include helping feel alert and awake.

"Physical activity may not just be good for the waistline and heart, but it also can help you sleep," Cardinal said. "There are trade-offs. It may be easier when you are tired to skip the workout and go to sleep, but it may be beneficial for your long-term health to make the hard decision and get your exercise."
http://www.medicalnewstoday.com/releases/238195.php

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The Effects Of Beer And Wine On The Risk Of Cardiovascular Disease

Research published in the European Journal of Epidemiology by Costanzo S, Di Castelnuovo de Gaetano G et al has sought to separate the effects of wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events. The Italian authors carried out an updated meta-analysis on the relationship between wine, beer or spirit consumption and cardiovascular outcomes, using state-of-the-art statistical techniques.

From 16 studies, results confirmed a J-shaped relationship between wine intake and reduced vascular risk, with maximal protection - an average 31% (95% confidence interval (CI): 19%) was observed at 21 g/day of alcohol. Similarly, from 13 studies a J-shaped relationship was apparent for beer (maximal protection: 42% (95% CI: 19%) at 43 g/day of alcohol). From 12 studies reporting separate data on wine or beer consumption, two closely overlapping dose-response curves were obtained suggesting maximal protection of 33% at 25 g/day of alcohol approximately (2 drinks/day by US standards and 3 units for the UK) for vascular diseases. A statistically significant association between spirits intake and vascular disease was not found.

A major problem with all meta-analyses is the inability to control for variables that were not included in the original reports. While there were adequate data to adjust for most of the usual confounders, there was no way to evaluate effects of the pattern of drinking (frequency, binge drinking, etc.) on the cardiovascular outcomes.

Limited data were available about the association of spirits intake and cardiovascular risk. While the trend was for a decrease in such risk with increasing spirits consumption, there was not a statistically significant relation in the meta-analysis based on 10 independent relationships using random models.

The key result of this meta-analysis is the finding of a very similar inverse association between the consumption of beer and the consumption of wine in relation to cardiovascular outcomes. While a similar association was not seen for spirits consumption, the data presented do not permit the conclusion that the key effects on cardiovascular disease are primarily due to the polyphenols in beer and wine. Similarly, the results do not permit the conclusion that the effect on cardiovascular disease is due primarily to the alcohol in these beverages. The lack of a similar J-shaped association for spirits may have been due to different drinking patterns (e.g., more binge drinking among consumers of spirits), as the pattern of drinking was not included as a confounder in the analyses.

http://www.medicalnewstoday.com/releases/238137.php

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Gene Finding May Help Scientists Combat Obesity And Diabetes

Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes.

The study, which was published in the November 25, 2011 print edition of The Journal of Biological Chemistry, focused on the melanocortin-3 receptor (MC3R), which normally responds to signals of nutrient intake.

"What we discovered was quite a surprise," said Scripps Research Associate Professor Andrew Butler, who led the study. "We thought that the actions of the receptor expressed in the brain would be critical for metabolic homeostasis. However, what we found is that actions of the receptor expressed outside the brain appear to be equally important."

The existence of drug targets in areas outside of the central nervous system (the body's "periphery") might help in the effort to develop drugs that influence metabolism without major side effects, Butler said.

The findings were made possible by the team's development of a new transgenic animal model, where expression of the MC3R gene can be selectively "switched on" in different cell types.

In the study, the suppression of MC3R expression in the brain and peripheral tissues had a marked impact on metabolic homeostasis (equilibrium). Interestingly, mice expressing the MC3R gene in the brain only displayed an obese phenotype (physical appearance) similar to those where all types of expression was suppressed, indicating that actions of this receptor in the brain are not sufficient to protect against weight gain. The finding that loss of MC3R activity in the periphery impairs metabolic homeostasis is startling, Butler said, and point to a distinct role for MC3R signaling in the peripheral tissues. However, how the actions of these receptors impacts on obesity remains to be determined.

"It's clear that these peripheral receptors are important and the new mouse model will let us explore that potential," Butler said.

http://www.medicalnewstoday.com/releases/238206.php

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L-arginine: Supplement Tested On Fit, Athletic Men Shows No Advantage

One of the most recent, popular supplements for athletes looking to boost performance comes in the form of a naturally-occurring amino acid called L-arginine.

The reason for its popularity is twofold says Scott Forbes, a doctoral student in exercise physiology. "First, L-arginine is a precursor for nitric oxide that is known to improve blood flow, which in turn may aid the delivery of important nutrients to working muscles and assist with metabolic waste product removal. Secondly, L-arginine has been shown to increase growth hormone levels in the blood."

The benefits of growth hormone are diverse, including increasing the use of fat as a fuel as well as insulin and insulin-growth factor-1 (IGF-1) levels. However, most of the research conducted on L-arginine has been in a clinical setting and the benefits for physically active individuals are not as established. In some cases they are conflicting.

"One of the reasons for this is that the amount an individual has to consume has not been clearly established and this information is rarely provided by the manufacturers of such products," explains Forbes, a doctoral student in exercise physiology.

For Forbes it was a theory worth testing - and he wanted to test two different L-arginine doses on healthy, athletic men - the group most likely to purchase this readily-available supplement.

"L-arginine is interesting for a few reasons," says Forbes. "It can increase growth hormone response, and so can increase muscle mass. Also it has an impact on insulin, which is another anabolic hormone. A recent hot topic has been about nitric oxide as a vasodilator. The theory is that if you can vasodilate your arteries you can potentially enhance blood flow to the muscles and enhance nutrient delivery and waste product removal."

L-arginine is also often prescribed for older adults with cardiovascular disease, endothelial dysfunction or hypertension for its vasodilation properties and is rarely studied in younger, more vigorous populations.

For this study, Forbes recruited 14, active, physically fit men (age: 25±5yrs; weight: 78.0±8.5kg; height: 179.4±4.7cm), who were free of nutritional supplements, to examine a low and high dose of oral L-arginine on blood L-arginine, markers of nitric oxide, growth hormone, insulin, and insulin-like growth factor-1. In the double-blind, randomized, placebo-controlled study participants were first pre-screened, completing a one-day food record which was analyzed for carbohydrates, protein and fat consumption and caloric intake, then required to follow a modified diet to regulate intake of food and water prior to being dosed with L-arginine.

"After a 10-hour overnight fast, and no breakfast, we gave them a different dose of L-arginine - either .075 g per kilogram of body mass for the low dose, .15 g per kg of body mass for the high dose, or a placebo," says Forbes.

Blood samples were drawn with the athlete at rest, every half hour for three hours after the L-arginine or placebo dose. The reason explains Forbes, is that "Previous studies show that two hours after consumption L-arginine tends to reach baseline again."

What Forbes found was that in healthy, young, physically active males the two different doses significantly elevated L-arginine concentrations in the blood at rest, and both a low dose and a high dose were equally effective in doing so, but neither dose promoted a significant increase in nitric oxide, growth hormone, insulin, or insulin-like growth factor-1.

So, according to the study, it appears that L-arginine's impact depends on one's current health status: the more healthy and athletic the person, the less they'll benefit from it.

Now that he's established how L-arginine impacts the fit, young body at rest, he's embarked on two more studies - one with strength-trained athletes and one with aerobically-trained athletes - cyclists in this case - to look at the impacts of L-arginine on the body during exercise. "This time we're looking at the effects of supplements under two extremes: aerobic and strength exercise.

"There's a lot of money in nutritional supplements," he adds. "The industry might not be too happy when they see the results at rest, but who knows, it may be different with exercise."

Forbes has completed both of the exercise studies and hopes to publish the results in the near future.
http://www.medicalnewstoday.com/releases/238156.php

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Coffee May Protect Against Endometrial Cancer

Long-term coffee consumption may be associated with a reduced risk for endometrial cancer, according to a recent study in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Edward Giovannucci, M.D., Sc.D., professor of nutrition and epidemiology at the Harvard School of Public Health, said coffee is emerging as a protective agent in cancers that are linked to obesity, estrogen and insulin.

"Coffee has already been shown to be protective against diabetes due to its effect on insulin," said Giovannucci, a senior researcher on the study. "So we hypothesized that we'd see a reduction in some cancers as well."

Giovannucci, along with Youjin Je, a doctoral candidate in his lab, and colleagues observed cumulative coffee intake in relation to endometrial cancer in 67,470 women who enrolled in the Nurses' Health Study. During the course of 26 years of follow-up, researchers documented 672 cases of endometrial cancer. Drinking more than four cups of coffee per day was linked with a 25 percent reduced risk for endometrial cancer. Drinking between two and three cups per day was linked with a 7 percent reduced risk. A similar link was seen in decaffeinated coffee, where drinking more than two cups per day was linked with a 22 percent reduced risk for endometrial cancer. Giovannucci said he hopes this study will lead to further inquiries about the effect of coffee on cancer because in this and similar studies, coffee intake is self-selected and not randomized. "Coffee has long been linked with smoking, and if you drink coffee and smoke, the positive effects of coffee are going to be more than outweighed by the negative effects of smoking," said Giovannucci. "However, laboratory testing has found that coffee has much more antioxidants than most vegetables and fruits."
http://www.medicalnewstoday.com/releases/238106.php

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BPA Levels Rise 1,221% After 5 Days Eating Canned Soup

Volunteers who had one can of soup per day for five days had urine BPA (bisphenol A) levels rise by over 1,221% compared to the same people who had consumed freshly made soup daily for five days, researchers from Harvard School of Public Health reported in JAMA (Journal of the American Medical Association). The authors say their study is one of the few to measure human BPA levels after consuming canned products.

Lead author, doctoral student, Jenny Carwile, who studies at the faculty's Department of Epidemiology, said:


"Previous studies have linked elevated BPA levels with adverse health effects. The next step was to figure out how people are getting exposed to BPA. We've known for a while that drinking beverages that have been stored in certain hard plastics can increase the amount of BPA in your body. This study suggests that canned foods may be an even greater concern, especially given their wide use."

Bisphenol A (BPA)

Bisphenol A or BPA, molecular formula C15H16O2, is an organic compound that is used to make polycarbonate plastic and epoxy resins, among other things. BPA is an estrogenic - it has properties which can mimic the effects of the human hormone estrogen - it is an endocrine disruptor.

BPA is added to the lining of foods and drinks cans and, according to studies, interferes with reproductive development in animals, including humans. BPA levels in humans have been associated with a higher risk of developing several diseases and conditions, including obesity, diabetes type 2, and cardiovascular diseases.

BPA has also been found in polycarbonate bottles, which are identified by recycling number seven, as well as dentistry sealants and composites.

In 2008, concern regarding BPA became a public theme in the media after the governments of several nations questioned its safety - many retailers in North America, Western Europe, Japan and Australasia made moves to remove BPA-containing food products from their shelves.

A 2010 US FDA (Food and Drug Administration) report expressed concern regarding exposure of BPA to fetuses, infants and young children. Canadian authorities declared BPA a toxic substance in 2010 - the first country to do so. BPA is banned in baby bottles in the European Union and Canada.

Prenatal exposure to BPA has been associated with subsequent neurological difficulties.

The Harvard Study on the impact of canned soup on human BPA levels

Jenny Carwile and Karin Michels set out to determine whether the consumption of canned soup might raise concentrations of urinary BPA, compared to the consumption of freshly-made soup.

Their 75 volunteers consisted of students and staff from the Harvard School of Public Health. They were divided into two groups:
  • One group ate a 12-ounce serving of canned soup (vegetarian), one a day for five days. Then they washed-out for two days. This was followed by a same-sized portion of 100% freshly-made soup once a day for five days.
  • The other group did the same, but the other way round; starting off with daily freshly made soup, followed by a two-day washout, and then five days of daily canned soup.
The urine sample results from the two groups were similar, and showed that at the end of the five days on canned soups their HPA urine concentrations were 1,221% higher, compared to levels at the end of five days on freshly-made soup.

Further studies are required to determine how long urine levels remain high, the researchers stressed. They suspect the higher BPA levels may be temporary.

Senior author, Karin Michels, said:


"The magnitude of the rise in urinary BPA we observed after just one serving of soup was unexpected and may be of concern among individuals who regularly consume foods from cans or drink several canned beverages daily. It may be advisable for manufacturers to consider eliminating BPA from can linings."


Funding: the Allen Foundation and the Environmental Epidemiology from the National Institute of Environmental Health Sciences both provided grants to pay for this study.

Written by Christian Nordqvist
http://www.medicalnewstoday.com/articles/238157.php

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Scientist Uses Vitamin B12 To Deliver Appetite-Suppressing Hormone Via Chewing Gum

Most people understand that serious weight loss requires changing attitudes toward what they eat and how often they exercise. But, what if the process could be aided by simply chewing a stick of gum after meals? That's the question a team of scientists, led by Syracuse University chemist Robert Doyle, is trying to answer. In a groundbreaking new study, Doyle's team demonstrated, for the first time, that a critical hormone that helps people feel "full" after eating can be delivered into the bloodstream orally.

Doyle's study was published online in the American Chemical Society's Journal of Medicinal Chemistry and is forthcoming in print. The journal is the most cited in the field and one of the leading primary research journals internationally. Doyle is an associate professor in the Department of Chemistry in SU's College of Arts and Sciences. He collaborated on the study with researchers from Murdoch University in Australia.

The hormone, called human PYY, is part of a chemical system that regulates appetite and energy. When people eat or exercise, PYY is released into the bloodstream. The amount of PYY that is released increases with the number of calories that are consumed. Past studies have shown that people who are obese have lower concentrations of PYY in their bloodstream both when fasting and after eating than their non-obese counterparts. Additionally, intravenous infusion of PYY into a volunteer group of obese and non-obese individuals increased the serum levels of the hormone and lowered the number of calories both groups consumed.

"PYY is an appetite-suppressing hormone," Doyle says. "But, when taken orally, the hormone is destroyed in the stomach and that which isn't destroyed has difficulty crossing into the bloodstream through the intestines."

What's needed is a way to disguise the PYY so that it can travel through the digestive system relatively unharmed. Several years ago, Doyle developed a way to use vitamin B12 as a vehicle for the oral delivery of the hormone insulin. B12 is able to pass through the digestive system with relative ease and carry with it insulin, or other substances, into the bloodstream. Similarly, his research team attached the PYY hormone to his patent-pending vitamin B12 system. "Phase one of this study was to show that we could deliver a clinically relevant amount of PYY into the bloodstream," Doyle says. "We did that, and we are very excited by the results."

The next step involves finding ways to insert the B12-PYY system into such things as chewing gum or an oral tablet to create a nutritional supplement to assist individuals in losing weight in much the same way as nicotine-laced gum is used to help people stop smoking. "If we are successful, PYY-laced gum would be a natural way to help people lose weight," he says. "They could eat a balanced meal, then chew a stick of gum. The PYY supplement would begin to kick in about three to four hours later, decreasing their appetite as they approach their next meal."
http://www.medicalnewstoday.com/releases/238089.php

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Exercise May Encourage Healthy Eating Via Brain Changes

Exercise may encourage healthy eating by changing parts of the brain that influence impulsive behaviour, according to a new review of the available literature by researchers from Spain and the US published in Obesity Reviews. The researchers conclude that in a society where we are surrounded by temptations and triggers that facilitate over-eating and excess, the part of the brain responsible for "inhibitory control" undergoes "relentless strain" (they note it has limited capacity anyway), and doing exercise on a regular basis enhances it.

"By enhancing the resources that facilitate 'top-down' inhibitory control, increased physical activity may help compensate and suppress the hedonic drive to over-eat," they write.

Obesity has been rising at an alarming rate in Spain in recent years, so much so that in some parts of Spain, the proportion of the population that is obese is higher than that in many parts of the United States, the country traditionally considered as having the highest obesity rates in the western world.

Also, in line with other countries in the Mediterranean, Spain has one of the highest rates of childhood obesity in Europe.

Co-author Dr Miguel Alonso Alonso, a Spanish neurologist working at the Harvard-affiliated Beth Israel Deaconess Medical Center in the US, told the press on Wednesday that many studies suggest "physical exercise seems to encourage a healthy diet. In fact, when exercise is added to a weight-loss diet, treatment of obesity is more successful and the diet is adhered to in the long run".

However, in order better to inform and improve current approaches and treatments for obesity, he and his co-authors, from the US and Spain, thought it might be useful to bring together what these "somewhat disparate, yet interrelated lines of literature" may have to say about the neurological underpinning of the link between exercise and weight loss.

"Designing effective weight-loss interventions requires an understanding of how these behaviours are elicited, how they relate to each other and whether they are supported by common neurocognitive mechanisms," they write.

There is evidence that regular physical exercise changes the working and structure of the brain. From their review, the researchers conclude these changes seem to support the idea that regular exercise improves the results of tests that measure the state of the brain's executive functions, and increases in connections in the grey matter and prefrontal cortex.

One of the brain's executive functions is "inhibitory control" which helps us keep check on impulsiveness, or to suppress inadequate, excessive or inappropriate behaviour toward a goal.

The researchers conclude that regular practice of physical exercise, in time, produces a "potentiating effect" on the brain's executive functions, including the ability for inhibitory control, and this helps us "resist the many temptations that we are faced with everyday in a society where food, especially hypercaloric food, is more and more omnipresent".

Exercise also brings other benefits, such as making the brain more sensitive to physiological signs of fulness. This helps not only to control appetite, but it also modifies the "hedonic" response to food stimuli, say the researchers. Thus the benefits of exercise occur in the short term (these affect metabolism) and in the long term (these affect behaviour).

Alonso Alonso and colleagues suggest it is important that social policies help and encourage people to practise sport and engage in physical exercise, whether at school, in urban settings, or daily life, with the help of public transport, pedestrianized areas and sports centres.

Written by Catharine Paddock PhD

http://www.medicalnewstoday.com/articles/238191.php

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Moderate Alcohol Intake Linked To Lower Female Diabetes Risk

Females in middle age who drink alcohol moderately and consume large amounts of refined carbohydrates have a 30% lower chance of developing diabetes type 2, compared to women with similar dietary habits who don't drink, researchers from the Harvard School of Public Health wrote in the American Journal of Clinical Nutrition. Examples of refined carbohydrate foods include sugary drinks, white bread, some pastas, and (polished) white rice.

The authors explained, as background information to their report, that very little prior research has focused on whether there might be an association between glycemic index load, glycemic index, alcohol consumption and diabetes type 2 risk.

Dr. Frank Hu and team set out to determine what impact alcohol intake (or lack of it) might have on diabetes risk in middle aged women whose refined carbohydrate (carb) intake was high. They tracked 81,827 women for 26 years. The women had participated in the Nurses' Health Study and were all free of diabetes type 2 when the study began.

Their cumulative averages of glycemic index, glycemic load, total carb intake and total alcohol intake were calculated every two to four years using questionnaires.

During the follow-up period 6,950 participants developed diabetes type 2.

They found that the women with a high refined-carb intake who consumed moderate amounts of alcohol had a 30% lower chance of developing diabetes type 2 compared to women whose refined-carb intake was also high but consumed no alcohol.

In an interview with Reuters news agency, Dr. Hu said:


"If you eat a high carb diet without drinking alcohol, your risk of developing diabetes is increased by 30 percent.

However, if you eat a high carb diet, but (drink) a moderate amount of alcohol, the increased risk is reduced."


The authors concluded in an Abstract in the journal:


"Our findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence."


The moderate drinkers in this study consumed an average of 0.8 once (24 grams) of alcohol each day, the equivalent of approximately two drinks each week. A very small percentage were classed as heavy drinkers - consuming at least two ounces of alcohol each day - they did not have a lower diabetes type 2 risk.

The authors stressed that their study should not encourage people to start drinking if they do not do so now. Rather, they encourage a diet low in refined carbs and high in whole grains. If you are a drinker, they added, you should do so with moderation.

Refined and unrefined grains

Refined grains have been milled so that their outer bran coating has gone, leaving just the endosperm. Examples include white rice, white pasta and white bread. When referring to rice, the term polished is often used with the meaning 'milled'.

Unpolished-rice
Unpolished long-grain rice with bran

Sona-masuri
Polished Indian sona masuri rice grains

In whole grain products, the germ and endosperm are still there. Bran is a good source of fiber, while the germ has protein, minerals and vitamins - the endosperm has carbohydrates (mainly in the form of starch).

Whole grains, also known as unrefined grains (unrefined carbs) are rich in antioxidants and phytochemicals - these help protect us against diabetes, some cancers and coronary heart disease. Some studies have demonstrated that individuals who consume at least three portions of whole grains each day have a lower risk of developing heart disease compared to people who don't.

wholegrain
Here you can see the bran, germ and endosperm

Written by Christian Nordqvist
http://www.medicalnewstoday.com/articles/238253.php

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Cholesterol Levels And Heart Disease Biomarkers In Diabetics Improved By Vitamin D-Fortified Yoghurt

People with diabetes are known to have an increased risk of heart disease. New research published in BioMed Central's open access journal BMC Medicine shows that regular consumption of a vitamin D-fortified yoghurt drink improves cholesterol levels and biomarkers of endothelial dysfunction, a precursor of heart disease, in diabetics.

Not having enough vitamin D affects the inner lining of blood vessels (endothelial cells) eventually leading to atherosclerosis and cardiovascular disease. Endothelial dysfunction can be measured by the increased levels of a set of biomarkers, such as serum endothelin-1, E-Selectin and MMP-9. In a double-blind trial, researchers from Tehran investigated the effect of vitamin D on the glycemic status, cholesterol levels and endothelial biomarkers of diabetics. Patients were given either a plain yoghurt drink (Doogh) or the same drink fortified with vitamin D twice a day for 12 weeks.

Researchers from the National Research Institute and Faculty of Nutrition and Food Technology had previously shown that a vitamin D-fortified yoghurt drink could improve the glycemic status of people with type 2 diabetes. In collaboration with Tehran University of Medical Sciences their new trial showed that vitamin D improved the fasting glucose, insulin, QUICK1 (a measure of insulin resistance), and found some improvement in long term HbA1c.

Dr Neyestani explained, "The patients who had taken the vitamin D yoghurt also had improved cholesterol levels with lower total cholesterol and LDL levels and an increase in HDL. All the improvements in cholesterol seemed to be due to the reduction in insulin resistance. The biomarkers of endothelial dysfunction, serum endothelin-1, E-Selectin and MMP-9, levels were also lower for the patients taking vitamin D."

Prof Djazayery continued, "Most of our patients were deficient in vitamin D at the start of the trial but the fortified yoghurt drink elevated most of their levels to normal. However, even amongst those who took the vitamin D supplement, some people (about 5%) remained deficient at the end of the 12 weeks. These people did not show the same improvements. Nevertheless for most diabetics with vitamin D deficiency this is an easy way to improve their outcome."

http://www.medicalnewstoday.com/releases/238199.php

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Consumption Of Processed Meats Associated With Prostate Cancer

Increased consumption of ground beef or processed meat is positively associated with aggressive prostate cancer, according to a study published in the online journal PLoS ONE.

The research team, led by John Witte of University of California, San Francisco, also found that the correlation was primarily driven by red meat that was grilled or barbequed, especially when well done.

They suggest that this result, which was determined based on the meat consumption habits of about 1,000 male participants, is due to increased levels of carcinogens in meat prepared these ways. The report furthers previous findings of the correlation between meat consumption and prostate cancer, and may help determine particular compounds that could be targeted for prostate cancer prevention.
http://www.medicalnewstoday.com/releases/238203.php

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Tuesday, November 22, 2011

How Not To Put On Weight During Thanksgiving - 15 Useful Suggestions

Nutritionists estimate that the average Thanksgiving meal ranges from 3,000 to 5,000 calories. If our daily needs should not exceed between 1,600 to 2,400 calories, it is not surprising that people complain about weight gain during the holidays. However, it is not the meal's core that makes you put on the pounds, but rather the nice trimmings and goodies that come with it.

It happens every year to too many of us. We spend the summer and early autumn getting fit, losing weight, until we feel well and look good. Only to be faced with darker evenings, colder weather which tends to keep us indoors more, two giant holidays which culminate in New Year's Eve.

We wake up on January 1st feeling guilty and unwell, and full of pious resolutions. The cycle repeats itself year after year.

Apart from the health risks in having a fluctuating bodyweight - some studies have indicated that a constant bodyweight is better for good long-term health, this never-ending battle is stressful, and may have an impact on our mental well-being.


Thanksgiving-Brownscombe
The First Thanksgiving at Plymouth(By Jennie A. Brownscombe - 1914)

The following tips may help slow down, and even prevent the seemingly inevitable weight gain that occurs during the coming months, starting with Thanksgiving:
  • Breakfast - the worst thing to do is to skip breakfast and arrive at your feast later on in the day starving. When humans are super hungry, they tend to eat considerably more than those who are not.
  • Chewing - digestion starts when we chew. The longer you spend chewing the fewer calories you will be consuming per minute. You will feel full more rapidly, compared to gulping everything down quickly.
  • Turkey skin - avoid it. Turkey skin has considerably more calories than the breast. Turkey skin is very high in fat.

    RoastTurkey
    Turkey skin has a lot of fat and calories
  • Hidden fats - supposedly healthy low fat foods, such as some vegetables, carrots, soups, or mashed potatoes may have been prepared with lots of butter and are laden with fat. If you are cooking, try putting a little less than you did last year. If you were not involved in their preparation, try to find out (discreetly) how they were prepared. If they are high it fat, go easy on them.
  • Side dishes - be careful. They may seem like delicious afterthoughts that you can slip in with no significance; unfortunately, many are high in calories and are easy to eat fast. The more lean turkey and vegetables you can eat the better.
  • Mashed potatoes with cauliflower - if you add cauliflower before you mash so that it makes up 25% of the whole mash, most people won't notice it. Cauliflower has fewer calories than potato.
  • Physical activity - try going for a walk during the morning of Thanksgiving before your meal. If you limit your meal to 2,500 calories, the walk might represent 10% of that. Compare that to consuming from 3,000 to 5,000 calories in one sitting and not walking at all.
  • Eggs - egg white is practically pure protein while the yolk is virtually pure fat. Bear that in mind when you are preparing foods
  • If you love it, eat it - if you really crave something, have it, but not too much. Portion control is the key, rather than virtuous abstention (which rarely works for long).
  • How many dinners? - in the USA the majority of people will sit down for more than one big meal during Thanksgiving. Be careful. Two huge meals will push your calorie intake for the day off the charts. Some people find that eating some foods at one sitting, and then the other foods during the next meal works better than trying to hold back on everything.
  • Fluid intake - to prevent dehydration, remember that alcoholic drinks, sugary sodas or coffee are no good - drink plenty of water. Sugary drinks are laden with 'empty calories', while water is calorie-free.
  • Seconds - if you are trying to watch your calories, don't have a second helping. You should not be hungry if you have chewed carefully, consumed plenty of water, and selected a good quantity of low calorie foods. If you are an invited guest, your hosts may pressure you into having some more. Be polite, but firm; simply say "That was really delicious. But, no thank you."
  • Finger foods - avoid them unless you are 100% sure they are healthy, low calorie foods. Finger foods tend to be fattening during the holidays; they can be eaten rapidly, increasing the rate at which you are consuming calories. Foods that require a knife and fork take longer to eat.
  • Be realistic - this is a festive occasion; a time for celebration. It is a feast. It may be more practical and effective if you try to focus on maintaining your body weight, rather than trying to lose weight on this occasion. If you eat carefully, do some exercise, and watch the size of your portions, there is a much better chance of success.
  • If you want to do what you like - some people can get away with it, but it requires a certain amount of discipline. I have known people who will do two hours that morning on a treadmill, elliptical machine (cross-trainer), or even run a semi-marathon. When the meal arrives, they eat to their heart's content and do not put on any weight. If you plan to do this, make sure you are fit enough. If you are not sure, check with your doctor.
Written by Christian Nordqvist
http://www.medicalnewstoday.com/articles/238096.php

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Friday, November 18, 2011

PCBs Lead To Reduced Bone Density, Stunted Growth In Turtles

Manufactured until 1977, and banned by the Environmental Protection Agency in 1979, pentachlorobiphenyls (PCBs) are chemicals still commonly found in the environment because they break down slowly. Now, a husband and wife research team at the University of Missouri and Westminster College in Fulton, Mo., have found that exposure to one of the chemicals has effects on growth and bone density in turtles. This knowledge could lead to insights on PCBs effects on humans and the environment.

"Turtles also are known as an 'indicator species' because they are often used as a gauge for the health of an entire ecosystem," said Dawn Holliday, co-researcher and assistant professor of biology at Westminster College in Fulton, Mo. "By finding the effects of PCBs on turtles, we can understand possible effects the chemicals might have on humans."

Researchers studied PCB 126, a version of the chemical compound once used in pesticides and electric transformers. PCBs are absorbed by eating exposed animals or drinking exposed water and are stored in fat cells. PCBs can affect the endocrine system and, thus, the regulation of hormones that control growth and other body functions.

Scientists know that people harbor PCBs in many tissues; however, little is known about the effect the chemicals have on people. Dawn Holliday said previous research on people accidentally exposed to the chemical through spills or accidents has shown correlations between exposure and stunted growth in humans.

"By studying the effect of PCB exposure on turtles, we can better understand how PCB exposure impacts people," said Casey Holliday, co-researcher and assistant professor of anatomy in the MU School of Medicine. "People are high on the food chain, and thus more susceptible to accumulation of PCBs. Smaller animals ingest PCBs. As large animals eat these smaller animals, the chemical stays in the food chain, as it is deposited in fat cells and doesn't leave the body. Even people not directly exposed to extreme amounts of PCB may see effects; this research will help us understand these effects better."

In the study, the researchers examined Diamondback terrapins (Malaclemys terrapin) that were exposed to an amount of PCB 126 that was equivalent to the exposure the reptiles would experience in an urban aquatic environment, such as the mid-Atlantic's Chesapeake Bay or Louisiana's wetlands. The turtles were exposed to the chemical for six months, and were compared to a group of unexposed turtles kept in the same laboratory. Exposed turtles were smaller, had more juvenile features, and lower bone density. In a previous study, Dawn Holliday found that PCB-exposed turtles had a lower metabolic rate.

The changes have an effect on the way the turtles function. When diving for long periods of time, turtles stored calcium in their shells to help maintain a normal physiological state while they hold their breath. Lower bone density means less calcium, possibly resulting in a reduced ability to stay underwater for very long. Additionally, turtles with low bone density may produce eggs with thinner shells, leaving them more susceptible to predators. Lower density may result in a softer shell, enabling more predators to eat turtles. Affected turtles may also have difficulty eating hard prey, such as crabs, because the reptiles have smaller, weaker jaws and cannot easily crack shells.
http://www.medicalnewstoday.com/releases/237860.php

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Association Between Illegal Drug Use And Abnormal Weight In Teens

A survey of more than 33,000 Italian high school students reveals that both underweight and overweight teens consume 20 to 40% more illegal drugs than their normal-weight peers.

Further analysis showed that the relationship between these two factors was largely mediated by psychosocial factors such as self-esteem, parents' educational level, and friendships.

Based on these results, the authors conclude that abnormal weight and substance abuse are not directly related in a cause-effect relationship, but instead are likely both due to common underlying social factors and dissatisfaction.

"Eating disorders have largely increased during the last decades, and obesity is a major public-health problem, especially since the phenomenon is spreading among children. Thus we believe that the results are important to better define targeted interventions", says Dr. Sabrina Moinaro.

http://www.medicalnewstoday.com/releases/237843.php

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Prevention Strategies Needed To Stop Americans Getting Fatter

In 2020, the vast majority of adults in America will be overweight or obese and more than half will suffer from diabetes or pre-diabetic conditions, according to projections presented by Northwestern Medicine researchers at the American Heart Association (AHA) Scientific Sessions in Orlando.

The AHA has set a target to help Americans improve their overall heart health by 20 percent in 2020. However, if current trends continue, Americans can expect only a modest improvement of six percent in overall cardiovascular health in 2020.

The implications of not increasing heart health by 20 percent by 2020 could be grave. Declining rates of sickness and death from cardiovascular disease may stall, and related health care costs, already projected to reach $1.1 trillion per year by 2030, could rise even further. That's according to study author Mark Huffman, M.D., assistant professor in preventive medicine and medicine-cardiology at Northwestern University Feinberg School of Medicine and a cardiologist at Northwestern Memorial Hospital.

Representative of all Americans, the study is based on patterns found in the National Health and Nutrition Examination Surveys (NHANES) from 1988 to 2008. The projected numbers on weight and diabetes, based on previous trends, follow.
  • In 2020, 83 percent of men and 72 percent of women will be overweight or obese.
Currently, 72 percent of men and 63 percent of women are overweight or obese (people who are overweight have a Body Mass Index (BMI) of 25 to 29kg/m2, people who are obese have a BMI of 30kg/m2 or greater).
  • In 2020, 77 percent of men and 53 percent of women will have dysglycemia (either diabetes or pre-diabetes). Currently, 62 percent of men and 43 percent of women have dysglycemia.
"To increase overall heart health by 20 percent, American adults would need to rapidly reverse these unhealthy trends - starting today," Huffman said. "In concert with individual choices, public health policies can be and should be effective tools to reduce smoking, increase access to healthy foods, and increase physical activity in daily life."

More people would need to improve health behaviors related to diet, physical activity, body weight and smoking and health factors, related to glucose, cholesterol and blood pressure.

"We've been dealing with the obesity trend for the past three decades, but the impact we project on blood sugar is a true shock," said Donald Lloyd-Jones, M.D., chair and associate professor of preventive medicine at the Feinberg School of Medicine, a physician at Northwestern Memorial Hospital and senior author of the study. "Those are some really scary numbers. When blood sugar goes up like that all of the complications of diabetes come into play."

Less than five percent of Americans currently are considered to have ideal cardiovascular health. The modest six percent improvement in cardiovascular health that is projected for 2020 means better cholesterol and blood pressure numbers for Americans and fewer smokers. Improvements in treatment and control of cholesterol and blood pressure with medication and declines in smoking would partially account for this small boost, but they wouldn't be enough to offset the weight and diabetes problems Americans face, Huffman said. Projected improvements in diet and physical activity also contribute to the six percent projection, but the absolute increase in Americans who consume ideal diets will remain less than two percent by 2020, if current trends continue.

"Since the 1960s cardiovascular disease death rates have substantially decreased, but if the weight and dysglycemia trends continue to increase, we are in danger of seeing a reversal of those gains," Huffman said.

Achieving a healthy weight through diet and physical activity is the best way most Americans can improve their cardiovascular health, but, as Huffman stressed, not smoking is the number one preventable cause of preventable death. Yet, one in five Americans still smoke.
http://www.medicalnewstoday.com/releases/237846.php

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